Serious: reduction of greenhouse gas emissions to sustainable levels.

trivial: airline boarding.

World hunger. My sciatica.

The integrity of our constitutional republic is the most pressing issue to me.
There should be stiff penalties for walking in the exit door at stores

"Never solve all your problems. Another one will jump up to take it's place".

That said: human trafficking/satanic ritual worship & ritual sacrifice of babies & children.

Trivial: My husband would magically and without prompting, put his dishes in the dishwasher...every time.

The Federal government is far too big. It has strayed too far from its constitutional authority.

Lobbying, lobbyists and the revolving doors between governmental agencies and the very industries they are supposed to be regulating. ...On the trivial side, I would like to see someone invent mirrored contact lenses. LOL.

I don't believe that American especially right wing American's can have faith in our government until the left wing and Democratic politicians are accountable for their crimes. While expensive investigation go on and on for Republican members, evident crimes of the same natural go unpunished for the left. I would like to see more Republican Congress men and women stand up for this. As for trivial I am tired of seeing senior citizen not being given their cost of living increases which are so minimal while benefits to illegal immigrants are a major expense to our government. Really, our seniors are begrudged this minute increase? They are being nickeled and dimed out of the market. Charging for plan B medical is ridiculous when illegals are getting full medicare.

Pollution, specifically plastics in our oceans.
Complete decriminalization of marijuana/cannabis.

Most pressing: election integrity.

If fair, honest elections are a certainty, then everything else can be resolved.

How about pressing with a trivial solution
Number 1 - Vitamins for children [copenhagenconsensus.com]
"Hoddinott, Rosegrant and Torero note that for about $100 per child, a bundle of interventions including micronutrients , improvements in diet quality and better care behaviours, chronic undernutrition could be reduced by 36 percent in developing countries. Chronic undernutrition has significant neurological consequences, adversely affecting the hippocampus, damaging chemical processes associated with spatial navigation, memory formation and reducing myelination of axon fibers. This damage leads to loss of cognitive abilities and hence lower incomes. Even in very poor countries such as Ethiopia and using very conservative assumptions, each dollar spent reducing chronic undernutrition has a $30 payoff. "

list of global problems ranked by Return on Investment -
2. Malaria 3. Immunization 4. Deworming of School Children 5. Tuberculosis 6. R and D farm tech to reduce effect of Global Warming on production 7. Disaster warning systems 8. Hospitals, etc...
[copenhagenconsensus.com]

Illegal immigration as it would solve a plethora of other major issues. Also remove marijuana from being in the same class as narcotics.

Starvation. As for trivial issues, I'd like to see public nudity be decriminalized.